It was the first hybrid to be created on the Isla Nublar. It was kept frozen and locked up in InGen's secret tunnels until it escaped. It's shown only in the Jurrasic Parks' Netflix animated web series Camp Cretaceous. It was discovered by the teens left at the Isla after the Indominus Rex's breakout. The Scorpius Rex had venomous spines on its elbow, tail & neck due to the presence of DNA of Scorpius fish in it. It was the deadliest hybrid created by Dr. Henry Wu. It had the ability to asexually reproduce. It wasn't put up for display since it was unfit for it as per Simon Masrani.

It was the first-ever known hybrid to the audience. Its appearances are in Jurassic World and Jurassic Park: Camp Cretaceous. Its breakout led to the closure of the park and the turning of Isla Nublar into an isle that was ruled by the free-roaming dinosaurs. When the owner of the park Simon Masrani tried to capture the Indominus Rex, his helicopter crashed and blasted in the pterodactyl enclosure of the park. In the end, it was killed during the fight with T-rex and Blue(velociraptor), and at the end, Mosasaurus attacked it and pulled it into its lagoon.