Zapping Bacteria:
It disrupts the membrane of bacterial cells with PL0206, a small protein that is attracted to the negatively charged environment inside a biofilm.
This method has been carried on Phase 1 clinical trial with 14 patients with prosthetic joint infections, where interim data looks promising.
Tearing it down:
It loosens two universal components of biofilms, known as DNA-B-II. Loosening the DNA scaffolding of the biofilms would cause a collapse of the structure.
Tested on two dozen bacterial species, no biofilms survived the disappearance of DNABII.
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