Results

When the mice were examined 6 months later, between 20% and 60% of their bone, skeletal muscle, liver, heart, and aorta carried the DNA fix . Progerin levels fell and lamin A levels rose in several tissues. Even though the mice were already 2 weeks old when treated, age 5 in human years, their aortas months later bore virtually no signs of the fibrous tissue growth or loss of smooth muscle cells seen in mice and children with progeria.