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The first significant flu pandemic started in Siberia and Kazakhstan, traveled to Moscow, and made its way into Finland and then Poland, where it moved into the rest of Europe. By the following year, it had crossed the ocean into North America and Africa. By the end of 1890, 360,000 had died.
This bubonic plague pandemic started in the Yunnan province in China. Over the next 20 years, rats carried the infectious fleas responsible for the disease to Hong Kong and port cities around the world.
It caused almost 10 million deaths.
No specific anti-viral therapies were available during the 1918 flu. That’s still largely true today, where most medical care for the flu aims to support patients, rather than cure them.