Old First Message: Exercise More. New First Message: Sit Less.

The most comprehensive review of the effects of sedentary behavior on health and risk of death has intensified the call to reduce time spent being sedentary as well as increasing physical activity.

The study determines that the physiological evidence now available should be used to sharpen public health and clinical practice guidelines to extend beyond just the broadly prescribed message to exercise more, and to move towards a more comprehensive message of "sit less, move more and exercise."