Results Obtained Post Psilocybin Treatment.

Participants were less emotionally avoidant and their cognitive functioning improved. The improvement in their depressive symptoms correlated with changes in the brain.

These changes lasted until the study ended three weeks after the second psilocybin dose. No such changes were seen in the brains of those who received escitalopram, suggesting that psilocybin acts differently on the brain than SSRIs.

“For the first time we find that psilocybin works differently from conventional antidepressants. The brain showed more flexibility, fluidity and less entrenched in negative thinking patterns."