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The discovery points toward a mechanism through which psilocybin acts therapeutically on the brain to treat individuals who experience mental health issues, marked by fixed patterns of thinking.
Scientists analyzed fMRI brain scans from 60 people who participated in two psilocybin trials.
In addition to the drugs, all the participants received the same type of psychotherapy.
Scans done before and after treatment, showed the psilocybin treatment notably reduced connections within the brain areas that are tightly connected in depression and various mental health issues experienced today
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Participants were less emotionally avoidant and their cognitive functioning improved. The improvement in their depressive symptoms correlated with changes in the brain.
These changes lasted until the study ended three weeks after the second psilocybin dose. No such changes were seen in the brains of those who received escitalopram, suggesting that psilocybin acts differently on the brain than SSRIs.
“For the first time we find that psilocybin works differently from conventional antidepressants. The brain showed more flexibility, fluidity and less entrenched in negative thinking patterns."
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