Butyrate, GLP-1, And Ozempic

The researchers found that one metabolite, butyrate, was the driver of this effect. Butyrate, a short-chain fatty acid (SCFA) produced by certain gut bacteria in the fiber fermentation process, stimulates the release of GLP-1, which we've come to understand plays such an important role in communicating to the brain that feeling of 'fullness' when we eat. Semaglutide drugs like Ozempic synthetically create this gut-brain scenario, though in a more potent way that doesn't face the same kind of rapid deterioration as when it occurs naturally.