165 A.D.: The Antonine Plague

165 A.D.: The Antonine Plague

It may have been an early appearance of smallpox that began with the Huns.
The Huns then infected the Germans, who passed it to the Romans and then returning troops spread it throughout the Roman empire.  This plague continued until about 180 A.D., claiming Emperor Marcus Aurelius as one of its victims.

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