What makes it hard to fall asleep even when very tired? - Deepstash

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What makes it hard to fall asleep even when very tired?

The mind continues analyzing, planning and problem-solving (D-P-O), especially if excessively stimulated before bed. Relaxation techniques help calm the mind by focusing it on the body and breath. They can reset wakefulness-promoting neuromodulators, easing the transition to sleep.


352 reads


Adenosine and Sleep Drive

Adenosine and Sleep Drive

Adenosine builds up the longer we are awake, creating a “sleep drive” or hunger. It binds to receptors in the brain that normally promote wakefulness. Caffeine promotes wakefulness by blocking adenosine receptors. Each person must determine how caffeine impacts them and at what times of day it is...


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Light: The Key Zeitgeber

Light, especially sunlight, is the strongest “time giver” (zeitgeber) for circadian rhythms and sleep. Melanopsin-containing retinal ganglion cells detect light and signal the central circadian clock, called the suprachiasmatic nucleus. Bright light in the morning advances your clock, while light...


406 reads

Circadian Clocks and Rhythms

We have an internal “clock” that regulates sleep-wake cycles over roughly 24 hours (circadian). It is most directly set by light exposure, especially sunlight. Sunrise triggers a rise in cortisol, promoting wakefulness. 12–16 hours later, the pineal gland releases melatonin, promoting sleepiness....


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How do circadian rhythms interact with and influence other biological processes?

Circadian rhythms arise from the central clock in the brain but impact the timing of physiological events throughout the body. They regulate hormones, body temperature, metabolism, hunger, immune function, and more. Disrupting them can lead to weight gain, diabetes, depression, and dementia over ...


329 reads

Master Your Sleep & Be More Alert When Awake — Key Takeaways

  • Get sunlight exposure, ideally first thing after waking. Use artificial light if needed. This sets your circadian clock and hormonal rhythms for the day.
  • Avoid overhead and electronic lights, especially blue light, 1–2 hours before bed.
  • Stick to a consistent sleep schedule, ...


368 reads


  • Magnesium, theanine, apigenin and melatonin are natural supplements that may aid sleep for some. However, they can disrupt circadian rhythms or have side effects, so consult a doctor before use. 
  • For some, naps and “non-sleep deep rest” like meditation or hypnosis reset focus and pro...


377 reads




Sharing key insights from top books, podcasts, and beyond. Embrace the path of continuous learning with me.

The podcast discusses how to optimize one's sleep-wake cycle by controlling light exposure, timing of food and exercise, and relaxation practices. It covers the role of adenosine, circadian rhythms, cortisol, and melatonin in regulating alertness and sleepiness. Viewing bright light, ideally sunlight, during the day and avoiding it at night helps to anchor one's circadian clock and hormonal cycles for better sleep, mood, and health.

More like this

How to Fall Asleep Fast

  • Develop a “power down” ritual before bed: shut off all electronics an hour or two before sleep and resume all work early in the day, to calm your mind.
  • Use relaxation techniques: proven methods include daily journaling, deep breathing exercises, meditation, exercise, and keeping a gr...


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