Given the growing evidence that shows lactate providing signal-regulatory functions in various cell types under physiological and pathological conditions, researchers hypothesized that lactate affects neuronal function through changing comprehensive gene expression.
The researchers tested their hypothesis by examining the gene regulation of cells treated with lactate.
They found that lactate indeed helps with neural differentiation, the process through which neural stem cells develop into specialized neurons.
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Researchers discovered the critical role that lactate - an exercise and metabolism byproduct - plays in brain development and neuronal differentiation, and in the modification and strengthening of neuronal functions. Their findings could serve as a basis for harnessing lactate for encouraging exercise or designing drugs to prevent or control cognitive diseases
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