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What Is Lactate?
Lactate is a byproduct of exercise and metabolism. Glucose gets converted into lactate when oxygen supplies to cells are limited, giving the brain a source of energy.
Lactate levels in fetal brains increase from the middle state of gestation, highlighting the significant role it has in brain development and neuronal differentiation.
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Lactate: Signaller And Controller
Recent studies and reports have demonstrated that lactate is a vital component of our nervous system.
They have shown that lactate functions as an important cellular signaling molecule in the nervous system, and that lactate metabolism is involved in neuronal functions, including neuroplasticity and memory consolidation.
However, the role of lactate signaling in neuronal cells has, until now, remained unknown.
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Lactate Aids In Neural Differentiation
Given the growing evidence that shows lactate providing signal-regulatory functions in various cell types under physiological and pathological conditions, researchers hypothesized that lactate affects neuronal function through changing comprehensive gene expression.
The researchers tested their hypothesis by examining the gene regulation of cells treated with lactate.
They found that lactate indeed helps with neural differentiation, the process through which neural stem cells develop into specialized neurons.
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Harnessing Lactate Signaling
The researchers believe their findings could serve as a basis for harnessing lactate signaling for encouraging exercise or designing drugs as a way to prevent or control cognitive diseases.
Their findings provide a novel insight into the mechanisms by which exercise-induced high serum lactate levels may beneficially affect the nervous system.
Furthermore, since the changes in lactate levels caused by human exercise can be measured, the adaptational changes in the brain function such as cognition and memory function can be better understood when changes in the lactate level is considered.
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CURATOR'S NOTE
Researchers discovered the critical role that lactate - an exercise and metabolism byproduct - plays in brain development and neuronal differentiation, and in the modification and strengthening of neuronal functions. Their findings could serve as a basis for harnessing lactate for encouraging exercise or designing drugs to prevent or control cognitive diseases
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