You take a group of group of young, healthy people, who presumably have lots of anabolic capacity. You put them in a cast for 1 week, and you immediately demonstrate, upon removing the cast, that the leg that has been immobile for a week is 35% less responsive to protein assimilation than the other leg. That’s an anabolic resistance factor of 35%, that is far greater than what you see in an aged individual.

So, with 1 week of inactivity, you (can) make a young leg or young muscle respond completely like a senescent muscle.