Optimizing Muscle Protein Synthesis: the Crucial Impact of Protein Quality and Quantity, and the Key Role of Resistance Training | Luc van Loon, Ph.D. - Deepstash

Explore the World's Best Ideas

Join today and uncover 100+ curated journeys from 50+ topics. Unlock access to our mobile app with extensive features.

LUC VAN LOON

Using that intrinsically labelled protein, I always have three different settings in my lectures.

The first one is, this intrinsically labelled protein shows you, beyond any discussion, that you are what you eat.

In fact, you are what you just ate.

LUC VAN LOON

19

348 reads

LUC VAN LOON

Now, funny enough, if you eat that same protein after you’ve done a little exercise, more of the protein is converted to muscle. So, if you’re physically active, you are MORE of what you just ate.

Then, to the third part of the lecture, I show you that with physical inactivity, you become anabolically resistant. So, if you become physically less active, you are LESS of what you just ate.

LUC VAN LOON

19

270 reads

LUC VAN LOON

Now, the problem is, when you become sick or you get surgery, you have two issues: you exercise less or you become less physically active, but you also eat less.

So, it’s a double whammy downwards. And that’s what makes us so vulnerable to a short period of inactivity or sickness.

LUC VAN LOON

17

258 reads

LUC VAN LOON

You take a group of group of young, healthy people, who presumably have lots of anabolic capacity. You put them in a cast for 1 week, and you immediately demonstrate, upon removing the cast, that the leg that has been immobile for a week is 35% less responsive to protein assimilation than the other leg. That’s an anabolic resistance factor of 35%, that is far greater than what you see in an aged individual.

So, with 1 week of inactivity, you (can) make a young leg or young muscle respond completely like a senescent muscle.

LUC VAN LOON

13

186 reads

LUC VAN LOON

And now the fun thing: you take an aged individual, who might have 20% or 30 % less anabolic response to protein than a young person. If you exercise them, you can bring them up to the same level as a young person.

These two factors suggest that activity might be the main determinant of anabolic resistance, and an aging individual or age within an individual is simply a proxy for activity.

So, muscle itself doesn’t seem to get that old. It actually still responds completely normal and we can normalize for age by physical activity.

LUC VAN LOON

14

175 reads

IDEAS CURATED BY

xarikleia

“An idea is something that won’t work unless you do.” - Thomas A. Edison

CURATOR'S NOTE

We (can) become more of what we eat or less of what we eat. | Age within an individual can simply be a proxy for activity. | Muscle itself doesn’t seem to get that old.

Similar ideas

Endless Student Syndrome

7 ideas

How to Lose 100 Pounds

12 ideas

How to Lose 100 Pounds

Mind Pump: Raw Fitness Truth

Read & Learn

20x Faster

without
deepstash

with
deepstash

with

deepstash

Personalized microlearning

100+ Learning Journeys

Access to 200,000+ ideas

Access to the mobile app

Unlimited idea saving

Unlimited history

Unlimited listening to ideas

Downloading & offline access

Supercharge your mind with one idea per day

Enter your email and spend 1 minute every day to learn something new.

Email

I agree to receive email updates