Spontaneous brain fluctuations

When our mind wanders, sleeps, or is under anaesthesia, our neurons are still firing all over the brain.

But through trauma, our spontaneous fluctuations can fall into negative resting-state patterns, almost like water that runs into a ditch. Antidepressants either cut off this water flow or reduce the functional connectivity, leaving around 70 percent of people who take antidepressants feeling an "emotional numbness".