Stages of Erythropoiesis (Simplified)

The production of all blood cells begins with the haemocytoblast , a multipotent haematopoietic stem cell.

Some differentiate to common myeloid progenitor cells, which produce erythrocytes, mast cells, megakaryocytes and myeloblasts.

Process of common myeloid progenitor cells to mature RBC -

1. normoblasts (aka eryhthroblasts), normally present in bone marrow. -Further classified into= a) Early Normoblast b) Intermediate Normoblast c) Late Normoblast
2. reticulocytes (normoblast lose organelles, nucleus) =immature RBC
3. erythrocytes (reticulocyte lose rest of the organelles) =mature RBC (survive 120 days)