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Paget's disease is a disruption of normal bone renewal cycle. It weakens and possibly deforms a bone.
Speaking of bone renewal cycle, there are 2 cells responsible for this outcome:
In Paget's disease however, there is an anomally in osteoclast cells where it absorbs bone at a much faster rate than normal.
The osteoblasts then try to produce new bone more quickly, but the new bone is larger and weaker than normal.
There are no possible reason for this yet but, some experts say that it might be the cause of genetics (e.g. lineage)
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Symptoms:
Paget's disease is an asymptomatic kind of disease. Sometimes, symptoms can be felt or seen with a naked eye. At times, patients appear normal.
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There is no known cure for this kind of disease but, it can still be treated to prevent further damage.
Main treatments:
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Paget's disease can further disrupt any normal structure of your bones. The fragile bones break more easily than normal. At times, it will enlarge then the bones turn misshapen.
Some patients even have a permanent hearing loss if the skull is affected. Also, in some parts of your organ, your heart can have a heart attack when there is a problem in the sternum (rib).
Take note that there is a high possibility that Paget's disease can turn into cancer.
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CURATOR'S NOTE
This is just a bunch of ideas I got from my Anaphy professor. I typed it here so I can go back to some ideas that I seem to find very helpful for my studies. Anyways, welcome to my cluttered notes. I hope this will also help other students in Med field. đ
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