Though the 2009 flu pandemic primarily affected children and young and middle-aged adults, the impact of the (H1N1)pdm09 virus on the global population during the first year was less severe than that of previous pandemics.
The (H1N1)pdm09 virus was very different from H1N1 viruses that were circulating at the time of the pandemic. Few young people had any existing immunity (as detected by antibody response) to the (H1N1)pdm09 virus, but nearly one-third of people over 60 years old had antibodies against this virus, likely from exposure to an older H1N1 virus earlier in their lives.
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There is the misconception that the first wave of the so-called Spanish flu was more lethal than the ones to follow. But in reality, the second (October-December 1918) out of the 3 waves had the highest rate of deaths.
During the second wave, those with severe cases were often crowded tog...
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