How weight loss affects our hormones

Studies found that diet-induced weight loss is associated with hormone changes that promote weight gain.

After weight loss, leptin levels will decrease. But ghrelin, GIP and pancreatic polypeptide will increase in circulation while PYY and CCK will lower. Most of these changes favour regaining lost weight. These hormonal changes seem to be present for at least one year after weight loss, leading to a constant increase in hunger.

The hypothalamus coordinates the body's system that regulates food intake.

• The hypothalamus contains nerve cells that produce the sensation of hunger when activated. They do so by making two distinct proteins that cause hunger.
• Close to thes...