One theory is that the more people are awake, the longer their neurons are active and the more amyloid (a protein in the brain that clumps into plaques in Alzheimer’s) is produced, Dr. Musiek said.
Another theory is that during sleep, fluid flowing in the brain helps clear out excess proteins, so inadequate sleep means more protein buildup.
Some scientists also think getting sufficient time in certain sleep phases may be important for clearing proteins
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