The vulnerability of an individual to these reactions can have a genetic link. Overreaction to innocuous antigens are linked to changes in the CD regions of T-helper cell membranes, explaining why reactions like peanut allergies can commonly run in families. Overreaction to self-antigens is normally due to a failure in central tolerance, and this failure can also have genetically-inheritable features.
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Hypersensitivity Reactions - Types - T cell - TeachMePhysiology
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