1. mTOR (Mammalian target of rapamycin)
Low levels of mTOR activates Autophagy (a signal that times are tough), the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier ones.
2. AMPK (AMP-activated protein kinase)
AMPK is a sensor of energy; low energy is a good thing for longevity. In response, it protects the body because it thinks it’s going to run out of food.
We get more AMPK through exercise and fasting.
3. Sirtuins
Sirtuins are a family of signaling proteins involved in metabolic regulation. They take care of DNA repair and stabilization of the epigenome.
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This is a summary of the first season of the Lifespan Podcast. Need to listen to the whole thing.
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