1. mTOR (Mammalian target of rapamycin)
Low levels of mTOR activates Autophagy (a signal that times are tough), the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier ones.
2. AMPK (AMP-activated protein kinase)
AMPK is a sensor of energy; low energy is a good thing for longevity. In response, it protects the body because it thinks it’s going to run out of food.
We get more AMPK through exercise and fasting.
Sirtuins are a family of signaling proteins involved in metabolic regulation. They take care of DNA repair and stabilization of the epigenome.
When the cells replicate, the best thing is that they replicate into the same type of cell (we have liver cells, skin cells, nerve cells, etc.).
As we age, the packaging of the DNA that allows a cell to remain of a certain type of cell forever starts getting lost.
This is the process that give birth to most diseases (Dementia, Alzheimer, Diabetes, Heart Disease). If you slow down Ex-differentiation, it means you are getting the cells to remember how to behave. And consequently, you reverse aging.
The 3 regulators (mTOR, AMPK and Sirtuins) slow down the Ex-differentiation process.
In the Morning:
At night: 800mg Metformin, after dinner. Not the night before doing weightlifting.
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