When the cells replicate, the best thing is that they replicate into the same type of cell (we have liver cells, skin cells, nerve cells, etc.).
As we age, the packaging of the DNA that allows a cell to remain of a certain type of cell forever starts getting lost.
This is the process that give birth to most diseases (Dementia, Alzheimer, Diabetes, Heart Disease). If you slow down Ex-differentiation, it means you are getting the cells to remember how to behave. And consequently, you reverse aging.
The 3 regulators (mTOR, AMPK and Sirtuins) slow down the Ex-differentiation process.
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This is a summary of the first season of the Lifespan Podcast. Need to listen to the whole thing.
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