Blocking Valence
Without neurotensin signaling in the BLA, mice could no longer assign positive valence and didn’t learn to associate the first tone with a positive stimulus. Interestingly, the absence of neurotensin did not block negative valence. The animals instead became even better at negative valence, having a stronger association between the second tone and a negative stimulus.
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Researchers discovered a specific neurotransmitter that helps assign either positive or negative emotions to memories. Their discovery paves the way for a better understanding of why some people are more likely to retain negative emotions than positive ones—as can occur with anxiety, depression or post-traumatic stress disorder (PTSD).
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