D-serin reversed physiological aging in mice

To test that, the authors delivered the gene for Menin into the hypothalamus of elderly (20-month-old) mice. 30 days later, they found improvements in skin thickness and bone mass, learning, cognition, and balance, which correlated with an increase in D-serine within the hippocampus.

Remarkably, similar benefits on cognition, (but not on the peripheral signs of aging) could be achieved by 3 weeks of dietary supplementation with D-serine.