The chain of cause and effect that leads to suffering:
1. Ignorance leads to reactions.
2. Reactions give rise to consciousness.
3. Consciousness creates mind and matter.
4. Mind and matter lead to the six senses.
5. The six senses cause contact with the world.
6. Contact generates sensations.
7. Sensations lead to craving or aversion.
8. Craving and aversion cause attachment.
9. Attachment leads to the process of becoming.
10. Becoming results in birth.
11. Birth leads to decay, death, and all forms of suffering.
Suffering arises from ignorance and perpetuates itself through these interconnected steps.
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