When the PFC gets damaged, it can alter your personality and interfere with your willpower. One recorded case of damage to the PFC was in 1848, when an iron went straight into the skull of Phineas Gage, blowing away his PFC. He survived, but had a complete personality change, became irreverent, indulging at times, impatient of restraint or advice.
States that inhibit our PFC are being drunk, sleep-deprived, or just distracted. It can lead us to focus on our impulses, rather than our long-term goals.
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