In 1992, the giant virus, or mimivirus, was first observed during the pneumonia outbreak in England. Later the mamavirus and the even larger pandoravirus stretched the human perception of what it means to be a virus.
Giant viruses are not known to affect human health dramatically. The Asfivirus - the African swine fever virus - transmits from tick to pigs and causes hemorrhagic fever. It is closely related to a giant virus from the sewage in Marseille.
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