DeepMind says it will release the structure of every protein known to science - Deepstash
DeepMind says it will release the structure of every protein known to science

DeepMind says it will release the structure of every protein known to science

Curated from: technologyreview.com

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Deepmind and Protein Structure

DeepMind took the world of biology by surprise when it solved a 50-year grand challenge with AlphaFold, an AI tool that predicts the structure of proteins. 

Now, its AI will predict the shapes of nearly every protein in the human body, as well as the shapes of hundreds of thousands of other proteins found in 20 of the most widely studied organisms, including yeast, fruit flies, and mice. The breakthrough could allow biologists from around the world to understand diseases better and develop new drugs.

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Proteins: A Primer

Proteins are made of long ribbons of amino acids, which twist themselves up into complicated knots. Knowing the shape of a protein’s knot can reveal what that protein does, which is crucial for understanding how diseases work and developing new drugs—or identifying organisms that can help tackle pollution and climate change. Figuring out a protein’s shape takes weeks or months in the lab. AlphaFold can predict shapes to the nearest atom in a day or two.

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Precision Predictions

In the new version of AlphaFold, predictions come with a confidence score that the tool uses to flag how close it thinks each predicted shape is to the real thing. Using this measure, DeepMind found that AlphaFold predicted shapes for 36% of human proteins with an accuracy that is correct down to the level of individual atoms. This is good enough for drug development, says Hassabis.

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