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David Hume, a 18th century philosopher, stated that no ought-judgement (prescriptive goal based) may be correctly inferred from a set of premises expressed in terms of is (facts). The implication being that if a reasoner only has access to non-moral and non-evaluative factual premises, the reasoner cannot logically infer the truth of moral statements.
This is considered to be an un-solvable philosophical problem. Any existing try ends up with presuppositions of certain goal. In order to go from "Riding motorcycles is bad" to "You ought not ride motorcycles" one has to define bad in accordance with a goal.
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Sam Harris, a popular neuro-scientist, proposed we move from an is to an ought by recognising that maximising our well-being is a universal factual goal:
"Let's assume there is only what *is*. Conscious minds experience the world through experiences. But some experiences suck. If you doubt this place your hand on a hot stove and report back."
Sam Harris however presuppose the goal of well-being. But that goal is mostly an *ought* disguised as an *is*, lacking a scientific definition and open to interpretation.
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