EBM is the integration of evidence, clinical expertise, and patient values and preferences. Factors influencing clinical expertise include judgement, clinical skills and personal experience. EBM requires life-long self-monitored learning to stay up-to-date with the most recent clinical interventions and techniques, as this information is constantly changing.

So you Want to Know About EBM... (Evidence-Based Medicine)

EBM aims to improve patient care quality and produce optimal patient outcomes. It is identifying and promoting clinical practices that work, and eliminating those that don't. Additionally, the precision, accuracy and power of the intervention must be critically assessed. This process furthers the development of critical thinking.

Why use EBM?

According to AK Akobeng, there are five main steps to properly practise EBM. The next few blocks will explore this concept.

The 5-Step Model

Formulate Answerable Clinical Questions (CQs)The key is to translate the clinical problem into an answerable clinical question (CQ) – e.g. “Is treatment A effective in irradicating disease B?”. CQs should be clear, focus directly on the presenting complaint, and be answerable in terms of clinical evidence available.Form clinical questions using the PICO method.“P” - the Patient themself and the Problem i.e. their medical history and presenting complaint.“I” - Intervention i.e. the treatment / test used.“C” - Comparison of various interventions.“O” - Outcome i.e. the predicted result.

STEP 1

Find the Evidence : SourceLook for evidence that will answer your CQ. Clinical databases (e.g. Archimedes) are relatively reliable and timesaving sources, compared to traditional textbooks and oral sources. The Cochrane Database - a collection of system reviews - is also widely used in the medical field.

STEP 2A

Find the Evidence : SearchBeing able to search these databases is another skill in and of itself. Firstly, extract keywords from your PICO framework e.g. Problem is Thrombosis and Intervention is Aspirin, therefore the search will include the words “Thrombosis Aspirin”. When conducting the search, use the operating word “AND” for search results including all keywords and “OR” for either/some of the keywords.

STEP 2B

Appraise the EvidenceNot all research evidence is made the same – some is high-quality and thorough, some isn’t. It is thus paramount that research evidence is appraised in terms of validity, importance, and applicability. The CASP (Critical Appraisal Skills Programme) tools developed by Oxford Univ. incorporate all of these factors and provide a framework for your appraisal.

STEP 3

Apply the EvidenceEstablish the efficacy, risks, availability, and cost of the proposed treatment/test/intervention, and discuss with the patient before proceeding. This establishes trust between the health care practitioner and the patient - a "therapeutic alliance" as Akobeng says.

STEP 4

Evaluate PerformanceSelf-monitoring and -auditing are fundamental in EBM practice. Ask yourself, "Am I following all 5 steps to the best of my ability?". This ensures that you are always providing the best possible patient care, and that favourable patient outcomes are strived for and ultimately, achieved.

STEP 5

A comprehensive summary of AK Akobeng's article on the Principles of Evidence Based Medicine.

The most important reason for practising EBM is to improve quality of care through the identification and promotion of practices that work, and the elimination of those that are ineffective or harmful.<a href="https://adc.bmj.com/content/90/8/837#ref-4">4 </a>EBM promotes critical thinking. It demands that the effectiveness of clinical interventions, the accuracy and precision of diagnostic tests, and the power of prognostic markers should be scrutinised and their usefulness proven. It requires clinicians to be open minded and look for and try new methods that are scientifically proven to be effective and to discard methods shown to be ineffective or harmful.

It is important that health care professionals develop key EBM skills including the ability to find, critically appraise, and incorporate sound scientific evidence into their own practice.

The practice of EBM involves five essential steps<a href="https://adc.bmj.com/content/90/8/837#ref-3">3, </a><a href="https://adc.bmj.com/content/90/8/837#ref-5">5 </a>: first, converting information needs into answerable questions; second, finding the best evidence with which to answer the questions; third, critically appraising the evidence for its validity and usefulness; fourth, applying the results of the appraisal into clinical practice; and fifth, evaluating performance.

Step 1: Formulating answerable clinical questions

One of the difficult steps in practising EBM may be the translation of a clinical problem into an answerable question.<a href="https://adc.bmj.com/content/90/8/837#ref-6">6 </a>When we come across a patient with a particular problem, various questions may arise for which we would like answers. These questions are frequently unstructured and complex, and may not be clear in our minds. The practice of EBM should begin with a well formulated clinical question. This means that we should develop the skill to convert our information needs into answerable questions. Good clinical questions should be clear, directly focused on the problem at hand, and answerable by searching the medical literature.<a href="https://adc.bmj.com/content/90/8/837#ref-7">7 </a>

A useful framework for making clinical questions more focused and relevant has been suggested by Sackett et al .<a href="https://adc.bmj.com/content/90/8/837#ref-1">1 </a>They proposed that a good clinical question should have four (or sometimes three) essential components:

<ul><li>the patient or problem in question; </li><li>the intervention, test, or exposure of interest; </li><li>comparison interventions (if relevant); </li><li>the outcome, or outcomes, of interest. </li> </ul>

Thus an answerable clinical question should be structured in the PICO (P atient or P roblem,I ntervention,C omparison,O utcome/s) or PIO (P atient or P roblem,I ntervention,O utcome/s) format.

To illustrate the concept of PICO/PIO, imagine that you have a four month old baby admitted to your ward with viral bronchiolitis. The child’s symptoms get progressively worse and you wonder whether giving corticosteroids might help the child improve and reduce the length of stay in hospital. You decide to use “clinical score” as a measure of improvement. The key components of your clinical question would be:

Patient or problem : 4 month old baby with viral bronchiolitis.

Intervention : corticosteroids.

Comparison : no corticosteroids.

Outcomes : clinical score, length of hospital stay.

A four part clinical question may be formulated as follows: In a 4 month old baby with viral bronchiolitis, does the administration of corticosteroids compared with not giving corticosteroids improve clinical score and reduce length of hospital stay?

Once you have formulated your clinical question, the next step is to seek relevant evidence that will help you answer the question. There are several sources of information that may be of help. Traditional sources of information such as textbooks and journals are often too disorganised or out of date.<a href="https://adc.bmj.com/content/90/8/837#ref-8">8 </a>You may resort to asking colleagues or “experts” but the quality of information obtained from this source is variable. Secondary sources of reliable summarised evidence which may help provide quick evidence based answers to specific clinical questions include Archimedes (<a href="http://adc.bmjjournals.com/cgi/collection/archimedes">http://adc.bmjjournals.com/cgi/collection/archimedes </a>),Clinical Evidence (<a href="http://www.clinicalevidence.com/ceweb/conditions/index.jsp">http://www.clinicalevidence.com/ceweb/conditions/index.jsp </a>), and BestBets (<a href="http://www.bestbets.org/index.html">http://www.bestbets.org/index.html </a>).

Other important sources of evidence include the online electronic bibliographic databases, which allow thousands of articles to be searched in a relatively short period of time in an increasing number of journals. The ability to search these databases effectively is an important aspect of EBM. Effective searches aim to maximise the potential of retrieving relevant articles within the shortest possible time. Studies have shown that, even in countries where hospitals have facilities for internet access allowing health care personnel access to a number of electronic databases, many people are not familiar with the process of carrying out efficient searches and often conduct searches which result in too few or too many articles.<a href="https://adc.bmj.com/content/90/8/837#ref-9">9, </a><a href="https://adc.bmj.com/content/90/8/837#ref-10">10 </a>It is therefore important for health care professionals to undergo basic training in search skills, either through their local library services or through the attendance at formal courses.

Convert the clinical problem into an answerable question

The key to successful searching is to convert your clinical problem into a clear answerable question, which should ideally be framed in the PICO/PIO format as discussed above.

A word list can be generated, based on keywords from the clinical question. For example, from the clinical question above, the following keywords could be used for the search: viral bronchiolitis (patient or problem ); corticosteroids and synonyms: glucocorticoids, steroids, prednisolone, dexamethasone (intervention ); clinical score, hospital stay (outcomes )

Numerous online databases are available. These include the Cochrane Library databases, MEDLINE, EMBASE, and CINAHL. In day to day clinical practice, I will suggest that becoming familiar with one or two databases will suffice in most cases. I recommend the Cochrane Library databases and MEDLINE. The Cochrane Library databases—which include the Cochrane database of systematic reviews, the Database of abstracts of reviews of effectiveness, and the Cochrane controlled trials register—is maintained by the Cochrane collaboration, an international initiative which began in the early 1990s and was designed to prepare, maintain, and disseminate systematic reviews of health care interventions.<a href="https://adc.bmj.com/content/90/8/837#ref-3">3 </a>The Cochrane Library is updated quarterly and is available through the internet or CD-rom. There is usually a charge for using the library, although NHS staff in the United Kingdom have free access to the service through the National Electronic Library for Health.

MEDLINE is probably the most widely used database for searching the biomedical literature.<a href="https://adc.bmj.com/content/90/8/837#ref-3">3 </a>It is maintained by the National Library of Medicine, USA. A version of MEDLINE (PUBMED) is freely available on the internet, is updated regularly, and is relatively user friendly.

When looking for articles on effectiveness of interventions or treatments, the first point of call should probably be the Cochrane database of systematic reviews or the other secondary sources mentioned above such as Archimedes, Clinical Evidence, and BestBets. The Cochrane controlled trials register provides an index of published randomised controlled trials. Randomised controlled trials and systematic reviews may also be searched for using MEDLINE. SUMsearch (<a href="http://sumsearch.uthscsa.edu/">http://sumsearch.uthscsa.edu </a>) is a useful search engine that allows direct searches of external databases with a focus on clinical topics.

Once the key words and databases have been identified, the next thing is to run the search. At the basic level, an efficient method is to combine individual words or terms using the Boolean operators “AND” and “OR”.<a href="https://adc.bmj.com/content/90/8/837#ref-11">11 </a>If you are combining two terms, AND allows only articles containing both terms to be retrieved, while OR allows articles containing either term to be retrieved. A simple Venn diagram consisting of two overlapping circles may be used to illustrate this principle. In fig 2A, the two terms have been combined using AND, and in fig 2B, they are combined using OR.

Venn diagram illustrating the use of Boolean operators AND and OR.

When too many articles come up after the initial search (which is often the case), PUBMED has a feature that allows you to limit the results of your search. You can limit your search by publication type (for example, randomised controlled trials or review articles); by date of publication; by language, by study population, and so on. PubMed also has a feature called “Clinical queries” which provides an easy to use approach to evidence based searching within the Medline database. “Clinical queries” is a preprogrammed research methodology filter that helps busy practitioners access the best available evidence by providing a quick access to reliable clinical studies related to therapy, diagnosis, aetiology, or prognosis.

To try to find evidence to answer the clinical question I formulated earlier, we can use the keywords generated to search the Cochrane database of systematic reviews and PUBMED, using the following search strategy:

<ul><li>: Viral bronchiolitis </li><li>: Corticosteroids OR steroids OR glucocorticoids OR prednisolone OR dexamethasone </li><li>: Clinical score OR hospital stay </li><li>: (1) AND (2) AND (3). </li> </ul>

When this search strategy was used to search the Cochrane database of systematic reviews on 10 December 2004, four articles were retrieved, but only one of these was relevant.<a href="https://adc.bmj.com/content/90/8/837#ref-12">12 </a>

Other strategies that may be used to improve the sensitivity and specificity of literature searches have been described by Sackett et al .<a href="https://adc.bmj.com/content/90/8/837#ref-1">1 </a>

After you have obtained relevant articles on a subject, the next step is to appraise the evidence for its validity and clinical usefulness. Although there is a wealth of research articles available, the quality of these is variable. Putting unreliable evidence into practice could lead to harm being caused or limited resources being wasted.

Research evidence may be appraised with regard to three main areas: validity, importance, and applicability to the patient or patients of interest. Critical appraisal provides a structured but simple method for assessing research evidence in all three areas.<a href="https://adc.bmj.com/content/90/8/837#ref-13">13 </a>Developing critical appraisal skills involves learning how to ask a few key questions about the validity of the evidence and its relevance to a particular patient or group of patients. Such skills may be learnt within small tutorials, workshops, interactive lectures, and at the bedside.<a href="https://adc.bmj.com/content/90/8/837#ref-13">13 </a>

Several tools for appraising research articles are available. I like the tools developed by the Critical Appraisal Skills Programme (CASP), Oxford, UK. These include tools for appraising randomised controlled trials, systematic reviews, case–control studies, and cohort studies. The CASP tools are simple, easy to use, and freely available on the internet.<a href="https://adc.bmj.com/content/90/8/837#ref-14">14 </a>

A detailed discussion of the critical appraisal of randomised controlled trials and systematic reviews will be provided in the next two articles of the series.

When we decide after critical appraisal that a piece of evidence is valid and important, we then have to decide whether that evidence can be applied to our individual patient or population. In deciding this we have to take into account the patient’s own personal values and circumstances. The evidence regarding both efficacy and risks should be fully discussed with the patient or parents, or both, in order to allow them to make an informed decision. This approach allows a “therapeutic alliance” to be formed with the patient and the parents and is consistent with the fundamental principle of EBM: the integration of good evidence with clinical expertise and patient values.<a href="https://adc.bmj.com/content/90/8/837#ref-15">15 </a>The decision to apply evidence should also take account of costs and the availability of that particular treatment in your hospital or practice. A practical illustration of issues to consider before applying research evidence will be provided in the fourth article of the series.

As we incorporate EBM into routine clinical practice, we need to evaluate our approach at frequent intervals and to decide whether we need to improve on any of the four steps discussed above. As Strauss and Sackett have suggested, we need to ask whether we are formulating answerable questions, finding good evidence quickly, effectively appraising the evidence, and integrating clinical expertise and patient’s values with the evidence in a way that leads to a rational, acceptable management strategy.<a href="https://adc.bmj.com/content/90/8/837#ref-15">15 </a>Formal auditing of performance may be needed to show whether the EBM approach is improving patient care.

EBM aims to improve quality of care through the integration of best research evidence with clinical expertise and patient’s and parents’ preferences. In this article, I have explained the five essential steps for practising EBM, which are: formulating answerable clinical questions; searching for evidence; making a critical appraisal; assessing the applicability of the evidence; and evaluating performance. The principles and critical appraisal of randomised controlled trials, systematic reviews, and meta-analyses, and a practical demonstration of the five step EBM model will be explored further in later articles in this series.

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Principles of Evidence Based Medicine - A K Akobeng (as summarised by S Carstens)

So you Want to Know About EBM... (Evidence-Based Medicine)

Why use EBM?

The 5-Step Model

STEP 1

STEP 2A

STEP 2B

STEP 3

STEP 4

STEP 5

IDEAS ABOUT

MORE LIKE THIS

Principles of evidence based medicine: Summary

Principles of evidence based medicine - PubMed

Principles of evidence based medicine

It's time to

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Bite-sized knowledgeto upgradeyour career

Principles of Evidence Based Medicine - A K Akobeng (as summarised by S Carstens)

So you Want to Know About EBM... (Evidence-Based Medicine)

Why use EBM?

The 5-Step Model

STEP 1

STEP 2A

STEP 2B

STEP 3

STEP 4

STEP 5

IDEAS ABOUT

MORE LIKE THIS

Principles of evidence based medicine: Summary

Principles of evidence based medicine - PubMed

Principles of evidence based medicine

It's time to

READ

LIKE

A PRO!

Bite-sized knowledge
to upgrade
your career