We pass out when the pressure drops below 57 percent of atmospheric pressure — equivalent to that at an altitude of 15,000 feet (4,572 meters). Climbers can push higher because they gradually acclimate their bodies to the drop in oxygen, but no one survives long without an oxygen tank above 26,000 feet (8,000 m, less than 356 millibars of atmospheric pressure).

How high can you go without oxygen?

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The effects of high altitude on humans are considerable. The <a href="https://en.wikipedia.org/wiki/Oxygen_saturation_(medicine)">oxygen saturation </a>of <a href="https://en.wikipedia.org/wiki/Hemoglobin">hemoglobin </a>determines the content of <a href="https://en.wikipedia.org/wiki/Oxygen">oxygen </a>in blood. After the <a href="https://en.wikipedia.org/wiki/Human_body">human body </a>reaches around 2,100 metres (6,900 ft) above sea level, the saturation of oxyhemoglobin begins to decrease rapidly.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-BordenHuman-1">[1] </a> However, the human body has both short-term and <a href="https://en.wikipedia.org/wiki/High-altitude_adaptation_in_humans">long-term adaptations </a>to altitude that allow it to partially compensate for the lack of oxygen. There is a limit to the level of adaptation; mountaineers refer to the altitudes above 8,000 metres (26,000 ft) as the <a href="https://en.wikipedia.org/wiki/Death_zone">death zone </a>, where it is generally believed that no human body can <a href="https://en.wikipedia.org/wiki/Acclimatization">acclimatize </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Darack-2">[2] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Huey-3">[3] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Grocott-4">[4] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-nodeath-5">[5] </a>

The human body can perform best at <a href="https://en.wikipedia.org/wiki/Sea_level">sea level </a>,<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-6">[6] </a> where the <a href="https://en.wikipedia.org/wiki/Atmospheric_pressure">atmospheric pressure </a>is 101,325 <a href="https://en.wikipedia.org/wiki/Pascal_(unit)">Pa </a>or 1013.25 <a href="https://en.wikipedia.org/wiki/Bar_(unit)">millibars </a>(or 1 <a href="https://en.wikipedia.org/wiki/Atmosphere_(unit)">atm </a>, by definition). The <a href="https://en.wikipedia.org/wiki/Atmospheric_chemistry">concentration of oxygen </a>(O2 ) in sea-level air is 20.9%, so the <a href="https://en.wikipedia.org/wiki/Partial_pressure">partial pressure </a>of O2 (pO2 ) is 21.136 kPa. In healthy individuals, this saturates <a href="https://en.wikipedia.org/wiki/Hemoglobin">hemoglobin </a>, the oxygen-binding red pigment in <a href="https://en.wikipedia.org/wiki/Red_blood_cells">red blood cells </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-7">[7] </a>

Atmospheric pressure decreases exponentially with <a href="https://en.wikipedia.org/wiki/Altitude">altitude </a>while the O2 fraction remains constant to about 100 km (62 mi), so pO2 decreases exponentially with altitude as well. It is about half of its sea-level value at 5,000 m (16,000 ft), the altitude of the <a href="https://en.wikipedia.org/wiki/Everest_Base_Camp">Everest Base Camp </a>, and only a third at 8,848 m (29,029 ft), the summit of <a href="https://en.wikipedia.org/wiki/Mount_Everest">Mount Everest </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-8">[8] </a> When pO2 drops, the body responds with <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#Acclimatization">altitude acclimatization </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Acclimatization-9">[9] </a>

Mountain medicine recognizes three altitude regions which reflect the lowered amount of oxygen in the atmosphere:<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-10">[10] </a>

<ul><li>High altitude = 1,500–3,500 metres (4,900–11,500 ft) </li><li>Very high altitude = 3,500–5,500 metres (11,500–18,000 ft) </li><li>Extreme altitude = above 5,500 metres (18,000 ft) </li> </ul>

Travel to each of these altitude regions can lead to medical problems, from the mild symptoms of <a href="https://en.wikipedia.org/wiki/Acute_mountain_sickness">acute mountain sickness </a>to the potentially fatal <a href="https://en.wikipedia.org/wiki/High-altitude_pulmonary_edema">high-altitude pulmonary edema </a>(<a href="https://en.wikipedia.org/wiki/HAPE">HAPE </a>) and <a href="https://en.wikipedia.org/wiki/High-altitude_cerebral_edema">high-altitude cerebral edema </a>(<a href="https://en.wikipedia.org/wiki/HACE">HACE </a>). The higher the altitude, the greater the risk.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-MedicalProblems-11">[11] </a> Expedition doctors commonly stock a supply of <a href="https://en.wikipedia.org/wiki/Dexamethasone">dexamethasone </a>, to treat these conditions on site.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-12">[12] </a> Research also indicates elevated risk of permanent brain damage in people climbing to above 5,500 m (18,045 ft).<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-fayed2006evidence-13">[13] </a>

Humans have survived for two years at 5,950 m (19,520 ft, 475 millibars of atmospheric pressure), which is the highest recorded permanently tolerable altitude; the highest permanent settlement known, <a href="https://en.wikipedia.org/wiki/La_Rinconada,_Peru">La Rinconada </a>, is at 5,100 m (16,700 ft).<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-highestHabitation-14">[14] </a>

At altitudes above 7,500 m (24,600 ft, 383 millibars of atmospheric pressure), sleeping becomes very difficult, digesting food is near-impossible, and the risk of HAPE or HACE increases greatly.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-MedicalProblems-11">[11] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid3215854-15">[15] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid1483750-16">[16] </a>

The <a href="https://en.wikipedia.org/wiki/Death_zone">death zone </a>in <a href="https://en.wikipedia.org/wiki/Mountaineering">mountaineering </a>, (originally the lethal zone ) was first conceived in 1953 by <a href="https://en.wikipedia.org/wiki/Edouard_Wyss-Dunant">Edouard Wyss-Dunant </a>, a Swiss physician and alpinist.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-17">[17] </a> It refers to altitudes above a certain point where the amount of <a href="https://en.wikipedia.org/wiki/Oxygen">oxygen </a>is insufficient to sustain <a href="https://en.wikipedia.org/wiki/Human">human </a>life for an extended time span. This point is generally tagged as 8,000 m (26,000 ft, less than 356 millibars of atmospheric pressure).<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-PBS-18">[18] </a> All 14 summits in the death zone above 8000 m, called <a href="https://en.wikipedia.org/wiki/Eight-thousander">eight-thousanders </a>, are located in the <a href="https://en.wikipedia.org/wiki/Himalaya">Himalaya </a>and <a href="https://en.wikipedia.org/wiki/Karakoram">Karakoram </a>mountain ranges.

Many deaths in high-altitude mountaineering have been caused by the effects of the death zone, either directly by loss of vital functions or indirectly through wrong decisions made under stress or physical weakening leading to accidents. In the death zone, the human body cannot acclimatize. An extended stay in the death zone without <a href="https://en.wikipedia.org/wiki/Bottled_oxygen_(climbing)">supplementary oxygen </a>will result in deterioration of bodily functions, loss of consciousness, and, ultimately, death.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Darack-2">[2] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Huey-3">[3] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Grocott-4">[4] </a>

As of 2021, studies have shown that the about 81.6 million people who live at elevations above 2,500 metres (8,200 ft) have adapted to the lower oxygen levels.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-jt-19">[19] </a> These adaptations are especially pronounced in people living in the <a href="https://en.wikipedia.org/wiki/Andes">Andes </a>and the <a href="https://en.wikipedia.org/wiki/Himalaya">Himalayas </a>. Compared with acclimatized newcomers, native Andean and Himalayan populations have better oxygenation at birth, enlarged lung volumes throughout life, and a higher capacity for exercise. Tibetans demonstrate a sustained increase in cerebral blood flow, elevated resting ventilation, lower hemoglobin concentration (at elevations below 4000 metres),<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-20">[20] </a> and less susceptibility to <a href="https://en.wikipedia.org/wiki/Chronic_mountain_sickness">chronic mountain sickness </a>(CMS).<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-21">[21] </a> Andeans possess a similar suite of adaptations but exhibit elevated hemoglobin concentration and a normal resting ventilation.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-22">[22] </a> These adaptations may reflect the longer history of high altitude habitation in these regions.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-23">[23] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-24">[24] </a>

A lower <a href="https://en.wikipedia.org/wiki/Mortality_rate">mortality rate </a>from <a href="https://en.wikipedia.org/wiki/Cardiovascular_disease">cardiovascular disease </a>is observed for residents at higher altitudes.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-25">[25] </a> Similarly, a <a href="https://en.wikipedia.org/wiki/Dose%E2%80%93response_relationship">dose–response relationship </a>exists between increasing elevation and decreasing <a href="https://en.wikipedia.org/wiki/Obesity">obesity </a>prevalence in the United States.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Voss-26">[26] </a> This is not explained by migration alone.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Voss1-27">[27] </a> On the other hand, people living at higher elevations also have a higher rate of <a href="https://en.wikipedia.org/wiki/Suicide">suicide </a>in the United States.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Brenner-28">[28] </a> The correlation between elevation and suicide risk was present even when the researchers control for known suicide risk factors, including age, gender, race, and income. Research has also indicated that oxygen levels are unlikely to be a factor, considering that there is no indication of increased <a href="https://en.wikipedia.org/wiki/Mood_disturbance">mood disturbances </a>at high altitude in those with <a href="https://en.wikipedia.org/wiki/Sleep_apnea">sleep apnea </a>or in heavy smokers at high altitude. The cause for the increased suicide risk is as yet unknown.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Brenner-28">[28] </a>

The human body can adapt to high altitude through both immediate and long-term acclimatization. At high altitude, in the short term, the lack of oxygen is sensed by the <a href="https://en.wikipedia.org/wiki/Carotid_bodies">carotid bodies </a>, which causes an increase in the breathing depth and rate (<a href="https://en.wikipedia.org/wiki/Hyperpnea">hyperpnea </a>). However, hyperpnea also causes the adverse effect of <a href="https://en.wikipedia.org/wiki/Respiratory_alkalosis">respiratory alkalosis </a>, inhibiting the <a href="https://en.wikipedia.org/wiki/Respiratory_center">respiratory center </a>from enhancing the respiratory rate as much as would be required. Inability to increase the breathing rate can be caused by inadequate carotid body response or pulmonary or renal disease.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-BordenHuman-1">[1] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-harris-29">[29] </a>

In addition, at high altitude, the <a href="https://en.wikipedia.org/wiki/Tachycardia">heart beats faster </a>; the <a href="https://en.wikipedia.org/wiki/Stroke_volume">stroke volume </a>is slightly decreased;<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-30">[30] </a> and non-essential bodily functions are suppressed, resulting in a decline in food digestion efficiency (as the body suppresses the <a href="https://en.wikipedia.org/wiki/Digestive_system">digestive system </a>in favor of increasing its cardiopulmonary reserves).<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-31">[31] </a>

Full acclimatization requires days or even weeks. Gradually, the body compensates for the respiratory alkalosis by renal excretion of bicarbonate, allowing adequate respiration to provide oxygen without risking alkalosis. It takes about four days at any given altitude and can be enhanced by drugs such as <a href="https://en.wikipedia.org/wiki/Acetazolamide">acetazolamide </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-harris-29">[29] </a> Eventually, the body undergoes physiological changes such as lower <a href="https://en.wikipedia.org/wiki/Lactic_acid">lactate </a>production (because reduced glucose breakdown decreases the amount of lactate formed), decreased <a href="https://en.wikipedia.org/wiki/Blood_plasma">plasma </a>volume, increased <a href="https://en.wikipedia.org/wiki/Hematocrit">hematocrit </a>(<a href="https://en.wikipedia.org/wiki/Polycythemia">polycythemia </a>), increased <a href="https://en.wikipedia.org/wiki/Red_blood_cell">RBC </a>mass, a higher concentration of <a href="https://en.wikipedia.org/wiki/Capillaries">capillaries </a>in <a href="https://en.wikipedia.org/wiki/Skeletal_muscle">skeletal muscle </a>tissue, increased <a href="https://en.wikipedia.org/wiki/Myoglobin">myoglobin </a>, increased <a href="https://en.wikipedia.org/wiki/Mitochondria">mitochondria </a>, increased <a href="https://en.wikipedia.org/wiki/Aerobic_respiration">aerobic </a>enzyme concentration, increase in <a href="https://en.wikipedia.org/wiki/2,3-Bisphosphoglycerate">2,3-BPG </a>, <a href="https://en.wikipedia.org/wiki/Hypoxic_pulmonary_vasoconstriction">hypoxic pulmonary vasoconstriction </a>, and <a href="https://en.wikipedia.org/wiki/Right_ventricular_hypertrophy">right ventricular hypertrophy </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-BordenHuman-1">[1] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-32">[32] </a> Pulmonary artery pressure increases in an effort to oxygenate more blood.

Full hematological adaptation to high altitude is achieved when the increase of red blood cells reaches a plateau and stops. The length of full hematological adaptation can be approximated by multiplying the altitude in kilometres by 11.4 days. For example, to adapt to 4,000 metres (13,000 ft) of altitude would require 45.6 days.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-33">[33] </a> The upper altitude limit of this linear relationship has not been fully established.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-nodeath-5">[5] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-highestHabitation-14">[14] </a>

Even when acclimatized, prolonged exposure to high altitude can interfere with <a href="https://en.wikipedia.org/wiki/Pregnancy">pregnancy </a>and cause <a href="https://en.wikipedia.org/wiki/Intrauterine_growth_restriction">intrauterine growth restriction </a>or <a href="https://en.wikipedia.org/wiki/Pre-eclampsia">pre-eclampsia </a>.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Moore-34">[34] </a> High altitude causes decreased blood flow to the <a href="https://en.wikipedia.org/wiki/Placenta">placenta </a>, even in acclimatized women, which interferes with fetal growth.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Moore-34">[34] </a> Consequently, children born at high-altitudes are found to be born shorter on average than children born at sea level.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-35">[35] </a>

For athletes, high altitude produces two contradictory effects on performance. For explosive events (sprints up to 400 metres, long jump, triple jump) the reduction in atmospheric pressure means there is less resistance from the atmosphere and the athlete's performance will generally be better at high altitude.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-36">[36] </a> For endurance events (races of 800 metres or more), the predominant effect is the reduction in oxygen, which generally reduces the athlete's performance at high altitude. One way to gauge this reduction is by monitoring VO2 max, a measurement of the maximum capacity of an individual to utilize O2 during strenuous exercise. For an unacclimated individual, VO2 max begins to decrease significantly at moderate elevation, starting at 1,600 metres and dropping 8 to 11 percent for every additional 1000 metres.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-37">[37] </a>

Sports organizations acknowledge the effects of altitude on performance: for example, the governing body for the <a href="https://en.wikipedia.org/wiki/Sport_of_athletics">sport of athletics </a>, <a href="https://en.wikipedia.org/wiki/World_Athletics">World Athletics </a>, has ruled that performances achieved at an altitude greater than 1,000 metres will be approved for record purposes, but carry the notation of "A" to denote they were set at altitude. <a href="https://en.wikipedia.org/wiki/1968_in_athletics#Altitude">The 1968 Summer Olympics </a>were held at altitude in <a href="https://en.wikipedia.org/wiki/Mexico_City">Mexico City </a>. Most short sprint and jump records were set there at altitude. Other records were also set at altitude in anticipation of those Olympics. <a href="https://en.wikipedia.org/wiki/Bob_Beamon">Bob Beamon </a>'s record in the <a href="https://en.wikipedia.org/wiki/Long_jump">long jump </a>held for almost 23 years and has only been beaten once without altitude or <a href="https://en.wikipedia.org/wiki/Wind_assistance#Long_jump">wind assistance </a>. Many of the other records set at Mexico City were later surpassed by marks set at altitude.

In 2007, <a href="https://en.wikipedia.org/wiki/FIFA">FIFA </a>issued a short-lived <a href="https://en.wikipedia.org/wiki/High-altitude_football_controversy">moratorium </a>on international matches held at more than 2,500 metres above sea level, effectively barring select stadiums in Bolivia, Colombia, and Ecuador from hosting <a href="https://en.wikipedia.org/wiki/FIFA_World_Cup">World Cup </a>qualifiers, including their capital cities.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-38">[38] </a> In their ruling, FIFA’s executive committee specifically cited what they believed to be an unfair advantage possessed by home teams acclimated to the elevation.

Athletes can also take advantage of altitude acclimatization to increase their performance.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-Acclimatization-9">[9] </a> The same changes that help the body cope with high altitude increase performance back at sea level. However, this may not always be the case. Any positive acclimatization effects may be negated by a de-training effect as the athletes are usually not able to exercise with as much intensity at high altitudes compared to sea level.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid9216951-39">[39] </a>

This conundrum led to the development of the altitude training modality known as "Live-High, Train-Low", whereby the athlete spends many hours a day resting and sleeping at one (high) altitude, but performs a significant portion of their training, possibly all of it, at another (lower) altitude. A series of studies conducted in Utah in the late 1990s showed significant performance gains in athletes who followed such a protocol for several weeks.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid9216951-39">[39] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid11509506-40">[40] </a> Another study from 2006 has shown performance gains from merely performing some exercising sessions at high altitude, yet living at sea level.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid16540709-41">[41] </a>

The performance-enhancing effect of altitude training could be due to increased red blood cell count,<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid16227463-42">[42] </a> more efficient training,<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid16227464-43">[43] </a> or changes in muscle physiology.<a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-44">[44] </a> <a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_note-pmid16339351-45">[45] </a>

<ol><li><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid9216951_39-0">a </a><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid9216951_39-1">b </a> <cite>Levine, BD; Stray-Gundersen, J (July 1997). ""Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance". Journal of Applied Physiology . 83 (1): 102–12. <a href="https://en.wikipedia.org/wiki/Doi_(identifier)">doi </a>:<a href="https://doi.org/10.1152%2Fjappl.1997.83.1.102">10.1152/jappl.1997.83.1.102 </a>. <a href="https://en.wikipedia.org/wiki/PMID_(identifier)">PMID </a> <a href="https://pubmed.ncbi.nlm.nih.gov/9216951">9216951 </a>. <a href="https://en.wikipedia.org/wiki/S2CID_(identifier)">S2CID </a> <a href="https://api.semanticscholar.org/CorpusID:827598">827598 </a>. </cite> </li><li><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid11509506_40-0">^ </a> <cite>Stray-Gundersen, J; Chapman, RF; Levine, BD (September 2001). ""Living high-training low" altitude training improves sea level performance in male and female elite runners". Journal of Applied Physiology . 91 (3): 1113–20. <a href="https://en.wikipedia.org/wiki/Doi_(identifier)">doi </a>:<a href="https://doi.org/10.1152%2Fjappl.2001.91.3.1113">10.1152/jappl.2001.91.3.1113 </a>. <a href="https://en.wikipedia.org/wiki/PMID_(identifier)">PMID </a> <a href="https://pubmed.ncbi.nlm.nih.gov/11509506">11509506 </a>. </cite> </li><li><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid16540709_41-0">^ </a> <cite>Dufour, SP; Ponsot, E.; Zoll, J.; Doutreleau, S.; Lonsdorfer-Wolf, E.; Geny, B.; Lampert, E.; Flück, M.; Hoppeler, H.; Billat, V.; Mettauer, B.; Richard, R.; Lonsdorfer, J. (April 2006). "Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity". Journal of Applied Physiology . 100 (4): 1238–48. <a href="https://en.wikipedia.org/wiki/Doi_(identifier)">doi </a>:<a href="https://doi.org/10.1152%2Fjapplphysiol.00742.2005">10.1152/japplphysiol.00742.2005 </a>. <a href="https://en.wikipedia.org/wiki/PMID_(identifier)">PMID </a> <a href="https://pubmed.ncbi.nlm.nih.gov/16540709">16540709 </a>. </cite> </li><li><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid16227463_42-0">^ </a> <cite>Levine, BD; Stray-Gundersen, J (November 2005). "Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume". Journal of Applied Physiology . 99 (5): 2053–5. <a href="https://en.wikipedia.org/wiki/Doi_(identifier)">doi </a>:<a href="https://doi.org/10.1152%2Fjapplphysiol.00877.2005">10.1152/japplphysiol.00877.2005 </a>. <a href="https://en.wikipedia.org/wiki/PMID_(identifier)">PMID </a> <a href="https://pubmed.ncbi.nlm.nih.gov/16227463">16227463 </a>. </cite> </li><li><a href="https://en.wikipedia.org/wiki/Effects_of_high_altitude_on_humans#cite_ref-pmid16227464_43-0">^ </a> <cite>Gore, CJ; Hopkins, WG (November 2005). "Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume". 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<ul><li><cite>Nosek, Thomas M. <a href="https://web.archive.org/web/20160324124828/http://humanphysiology.tuars.com/program/section4/4ch7/s4ch7_32.htm">"Section 4/4ch7/s4ch7_32" </a>. Essentials of Human Physiology . Archived from <a href="http://humanphysiology.tuars.com/program/section4/4ch7/s4ch7_32.htm">the original </a>on 24 March 2016. </cite> </li><li><a href="http://www.altitudeclinic.com/">IPPA </a>, High Altitude Pathology Institute. </li> </ul>

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