Jet Lag is a debility similar to a hangover. Jet Lag derives from the simple fact that jets travel so fast they leave your body rhythms behind.
Our biological clocks are synchronized to a 24-hour period. Our internal clocks drive our circadian rhythms, which anticipate dawn and dusk, and control everything from blood pressure to how hungry we are. When we fly to a different time zone, (or work night shifts), our internal clocks go out of sync.
Our bodies take a few days to fully adjust, depending on not only how many time zones have been crossed, but also the direction of travel.
Usually, it would take five or six days to adjust to a six-hour shift in time zone. When you travel east, your body has a shorter time to synchronize with the regular 24-hour sun cycle. When you travel west, your body has extra time to adjust.
Generally, the best way to fool your biological clock is to shift your internal rhythms before the flight.
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